The area was divided into industrial and residential districts, and the company installed lighting, sewer connections, and water distributions in the residential areas.
A second corporation, eventually known as the Western Meat Company, set up stock yards and meat packing facilities on 80 acres (32 ha) of bayfront property; the facility opened in 1892.
There were 20,870 housing units at an average density of 2,283.1 per square mile (881.6/km²).
There were 20,118 households out of which 39.2% had children under the age of 18 living with them, 51.8% were married couples living together, 11.2% had a female householder with no husband present, and 28.5% were non-families.
South San Francisco has mild winters and dry cool summers.
The hills to the west shield the eastern parts of the city from some of the fog that prevails in neighboring areas.
Their village of Urebure on San Bruno Creek was visited by the Gaspar de Portolà expedition in 1769; remains of long-term (5,000 years) inhabitancy and seasonal encampments have been examined at the Siplichiquin shell-mounds on San Bruno Mountain.
It has tripled since World War II with the opening of such subdivisions as Buri Buri, Winston Manor and Westborough on the slopes west of El Camino; The city is particularly noted for the South San Francisco hillside sign on Sign Hill, which rises to the north of the city, with large white letters that proclaim "South San Francisco, The Industrial City".At the end of the war the city's focus shifted away from "smokestack industries" toward light industry, warehousing, and residential development.The major manufacturers closed, and new development was focused on office parks, housing, high-rise hotels, and yacht harbors.The biotechnology giant Genentech opened in 1976, leading to South San Francisco's new identity as "the birthplace of biotechnology".) of it (69.69%) is water.South San Francisco lies north of San Bruno and San Francisco International Airport in the Colma Creek valley south of Daly City, Colma, Brisbane, and San Bruno Mountain; east of Pacifica and the hills of the northern Coast Range lying along the San Andreas Fault; west of the waters of San Francisco Bay.